Radiotherapy-enhanced ototoxicity in elderly
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چکیده
منابع مشابه
The effect of radiotherapy on gentamicin ototoxicity: an animal model.
OBJECTIVE Patients undergoing radiotherapy (RT) often present with serious bacterial infections requiring the use of antibiotic treatment. Gentamicin is a commonly used aminoglycoside antibiotic, whose ototoxicity remains a major problem in clinical use. The objective of this study was to determine whether radiation exposure can influence gentamicin-induced ototoxicity. STUDY DESIGN Prospecti...
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PURPOSE To investigate the incidence of radiation-induced ototoxicity according to the total dose delivered to specific parts of the auditory system, fractionation, and chemotherapy. METHODS AND MATERIALS Records of 325 patients treated for primary extracranial head and neck tumors with curative intent who received radiotherapy between 1964 and 2000 (median follow-up, 5.4 years) were retrospe...
متن کاملAuditory monitoring in ototoxicity.
UNLABELLED Some pharmaceutical products are capable of damaging the human auditory system. Technological progress has provided numerous resources to monitor hearing but there still is some controversy regarding the selection of the most sensitive and specific tests. OBJECTIVE to analyze audiological procedures used in the auditory monitoring of individuals exposed to ototoxic medication. ME...
متن کاملLow early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy
BACKGROUND Hearing loss is common following chemoradiotherapy for children with medulloblastoma. Compared to photons, proton radiotherapy reduces radiation dose to the cochlea for these patients. Here we examine whether this dosimetric advantage leads to a clinical benefit in audiometric outcomes. METHODS From 2006-2009, 23 children treated with proton radiotherapy for medulloblastoma were en...
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BACKGROUND Tamoxifen is an anti-estrogen with proven efficacy and low toxicity in the treatment of breast cancer. However, tamoxifen has been shown to exert a number of nonhormonal as well as hormonal effects. One nonhormonal effect of tamoxifen is the induction of transforming growth factor-beta (TGF-beta) secretion. TGF-beta has been implicated in the pathogenesis of radiation-induced fibrosi...
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ژورنال
عنوان ژورنال: South Asian Journal of Cancer
سال: 2014
ISSN: 2278-330X,2278-4306
DOI: 10.4103/2278-330x.142982